Abstract | BACKGROUND: METHODS: Forty-seven obese youth, 15 Ab+ and 32 Ab-, were divided into three OGTT-GRC groups: incessant increase, monophasic, and biphasic. The prevalence of OGTT-GRC, clamp-measured insulin sensitivity, and β-cell function was compared. RESULTS: Incessant increase OGTT-GRC is the most frequent curve type and is three-fold higher in Ab+ vs. Ab- youth CDX-T2D. In Ab+ youth, there was up to 40% lower second-phase insulin secretion in the incessant increase group vs. the other two groups combined (monophasic and biphasic). In Ab- youth, while first- and second-phase insulin secretion was significantly lower in the incessant increase vs. the other two groups combined, overall β-cell function was less impaired than in Ab+ youth. In neither Ab- or Ab+ youth was OGTT-GRC related to hepatic or peripheral insulin sensitivity. CONCLUSION: Severe insulin deficiency, a characteristic of type 1 diabetes, seems to be related to higher prevalence of incessant increase in Ab+ vs. Ab- obese youth.
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Authors | Joon Young Kim, Hala Tfayli, Fida Bacha, Silva Arslanian |
Journal | Journal of obesity & metabolic syndrome
(J Obes Metab Syndr)
Vol. 30
Issue 2
Pg. 178-183
(Jun 30 2021)
ISSN: 2508-7576 [Electronic] Korea (South) |
PMID | 34059560
(Publication Type: Journal Article)
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