Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: OBJECTIVE: The present study aimed to examine GLXBBX's preventative capacity and elucidate the potential molecular mechanism of Poloxamer 407 (P407)-induced hyperlipidemia in rats. MATERIALS AND METHODS: Both the control and model groups received pure water, and the test group also received a GLXBBX decoction. For each administration, 3 ml of the solution was administered orally. To establish hyperlipidemia, a solution mixed with 0.25 g/kg P407 dissolved in 0.9% normal saline was injected slowly into the abdominal cavity. At the end of the study, the rats' plasma lipid levels were calculated using an automatic biochemical analyzer to evaluate the preventative capability of the GLXBBX decoction, and the serum and liver of the rats were collected. RESULTS: CONCLUSION: GLXBBX significantly improved P407-induced hyperlipidemia, which may have been related to enhanced LPL activity, increased LPL mRNA expression, and decreased mRNA expression of SCD1.
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Authors | Mingzhu Luo, Rong Fan, Xiaoming Wang, Junyu Lu, Ping Li, Wenbin Chu, Yonghe Hu, Xuewei Chen |
Journal | Bioscience reports
(Biosci Rep)
Vol. 41
Issue 6
(06 25 2021)
ISSN: 1573-4935 [Electronic] England |
PMID | 34036306
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Author(s). |
Chemical References |
- Biomarkers
- Drugs, Chinese Herbal
- Hypolipidemic Agents
- Lipids
- gualou xiebai banxia decoction
- Poloxamer
- Stearoyl-CoA Desaturase
- stearoyl-CoA desaturase SCD-1, rat
- Lipoprotein Lipase
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Topics |
- Animals
- Biomarkers
(blood)
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology)
- Hyperlipidemias
(blood, chemically induced, prevention & control)
- Hypolipidemic Agents
(pharmacology)
- Lipids
(blood)
- Lipoprotein Lipase
(genetics, metabolism)
- Male
- Poloxamer
- Rats, Wistar
- Stearoyl-CoA Desaturase
(genetics, metabolism)
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