Targeting CD123 in hematologic malignancies: identifying suitable patients for targeted therapy.

Abstract

Following the observation of interleukin 3 receptor α chain (IL-3Rα; CD123) upregulation on leukemia stem cells (LSCs) almost two decades ago, targeted treatment via CD123-diptheria toxin conjugates has now been tested in patients with diverse myeloid malignancies. Targeted eradication of LSCs could result in effective treatments for many challenging diseases initiated by these cells. Consequently, considerable effort has been directed toward targeting CD123 as a potential strategy for treating patients with hematologic malignancies in which CD123 is overexpressed. However, these therapies have had limited success so far, highlighting the need for suitable criteria to identify patients who could benefit from them. Given the diversity in CD123 expression across different hematologic malignancies, understanding CD123 expression patterns and the functional pathogenetic significance is crucial. Here, we review the methodologies available for CD123 assessment and discuss the biological and clinical characteristics of patients for whom CD123-targeting therapies may have a clinical impact.

• Authors: Mrinal M Patnaik, Tariq I Mughal, Christopher Brooks, Ross Lindsay, Naveen Pemmaraju
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 62 Issue 11 Pg. 2568-2586 (11 2021) ISSN: 1029-2403 [Electronic] United States
• PMID: 33999767 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Interleukin-3 Receptor alpha Subunit

Topics

• Hematologic Neoplasms (diagnosis, drug therapy)
• Humans
• Interleukin-3 Receptor alpha Subunit
• Leukemia, Myeloid, Acute
• Myeloproliferative Disorders