Abstract | BACKGROUND: METHODS: Electronic databases were searched for appropriate randomized clinical trials. Odds ratio (OR) with 95% confidence intervals (95% CI) was used as the effect estimate. A random-effects model was used for generating the pooled estimates. Rankogram plot was used for ranking the drugs. MAIN OUTCOME MEASURES: Proportions of patients with remission (partial/complete) and with complete remission. RESULTS:
Mometasone (OR 6.53, 95% CI 2.85, 14.96), betamethasone/ hyaluronidase (OR 12.1, 95% CI 4.27, 34.49), triamcinolone (OR 19.15, 95% CI 4.47, 81.96), dexamethasone (OR 21.38, 95% CI 5.71, 79.98), betamethasone (OR 23.02, 95% CI 6.92, 79.54), hydrocortisone (OR 23.2, 95% CI 5.91, 91.02) and methylprednisolone (OR 50.47, 95% CI 4.45, 572.72) were observed with significantly higher proportions of patients with remission (partial/complete) compared to placebo. Dexamethasone, triamcinolone, betamethasone, betamethasone/ hyaluronidase, clobetasol, mometasone, and hydrocortisone were observed with significantly higher proportions of patients with complete remission compared to placebo. Beclomethasone was not observed to be superior to either placebo or other drugs. Rankogram plot revealed methylprednisolone followed by hydrocortisone had the maximum statistical probability of being 'the best' in the pool for remission and betamethasone followed by hydrocortisone for complete remission. CONCLUSION:
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Authors | Kannan Sridharan, Gowri Sivaramakrishnan |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 37
Issue 8
Pg. 1117-1125
(Aug 2021)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 33991205
(Publication Type: Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Hydrocortisone
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Topics |
- Administration, Topical
- Adrenal Cortex Hormones
(administration & dosage)
- Child
- Humans
- Hydrocortisone
(administration & dosage)
- Male
- Network Meta-Analysis
- Phimosis
(drug therapy)
- Randomized Controlled Trials as Topic
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