Abstract | BACKGROUND: METHODS: RESULTS: Among the patients taking clozapine and typical antipsychotic drugs, the RBANS total score, immediate memory, attention, and delayed memory subscores in females were higher than those in males (all p < 0.05). The RBANS total score and the delayed memory subscores in female patients taking risperidone were higher than those in male patients (all p < 0.05). Significant correlation between BDNF and cognition only existed in male patients taking clozapine, male patients taking risperidone, and male and female patients taking typical antipsychotic drugs (all p < 0.05). CONCLUSION: Regardless of antipsychotic effect, the cognitive function of female patients is better compared to that of male patients. For male patients, the association between BDNF and cognitive performance exists in each medication group. For female patients, this significant association was only shown in the typical antipsychotic group, but not in the clozapine and risperidone groups.
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Authors | Rui Dong, Ning Olivia Zhao, Hanjing Emily Wu, Liling Yu, Xiang Yang Zhang |
Journal | Journal of psychiatric research
(J Psychiatr Res)
Vol. 138
Pg. 492-499
(06 2021)
ISSN: 1879-1379 [Electronic] England |
PMID | 33971483
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antipsychotic Agents
- Brain-Derived Neurotrophic Factor
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Topics |
- Antipsychotic Agents
(therapeutic use)
- Brain-Derived Neurotrophic Factor
- Cognitive Dysfunction
(drug therapy, etiology)
- Female
- Humans
- Male
- Schizophrenia
(drug therapy)
- Sex Characteristics
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