The potential role of nucleophosmin (NPM1) in the development of cancer.

Abstract

Nucleophosmin (NPM1) is a well-known nucleocytoplasmic shuttling protein that performs several cellular functions such as ribosome biogenesis, chromatin remodeling, genomic stability, cell cycle progression, and apoptosis. NPM1 has been identified to be necessary for normal cellular functions, and its altered regulation by overexpression, mutation, translocation, loss of function, or sporadic deletion can lead to cancer and tumorigenesis. In this review, we focus on the gene and protein structure of NPM1 and its physiological roles. Finally, we discuss the association of NPM1 with various types of cancer including solid tumors and leukemia.

• Authors: Fateme Karimi Dermani, Saeideh Gholamzadeh Khoei, Saeid Afshar, Razieh Amini
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 236 Issue 11 Pg. 7832-7852 (11 2021) ISSN: 1097-4652 [Electronic] United States
• PMID: 33959979 (Publication Type: Journal Article, Review)
• Copyright: © 2021 Wiley Periodicals LLC.

Chemical References

• Biomarkers, Tumor
• NPM1 protein, human
• Nucleophosmin

Topics

• Animals
• Biomarkers, Tumor (genetics, metabolism)
• Cell Transformation, Neoplastic (genetics, metabolism, pathology)
• Disease Progression
• Gene Expression Regulation, Neoplastic
• Humans
• Mutation
• Neoplasms (genetics, metabolism, pathology)
• Nucleophosmin (genetics, metabolism)
• Signal Transduction