Laparoscopic Hepatectomy for the Patient with Hemophilia A with High Titer Factor VIII Inhibitor.

Abstract

We present the first case of laparoscopic left lateral segmentectomy for hepatocellular carcinoma (HCC) in a patient with hemophilia A, acquired hepatitis C, and high-titer factor VIII inhibitor, which was confirmed by preoperative diagnosis. He underwent laparoscopic left lateral segmentectomy with the administration of recombinant activated factor VII. Surgery could be performed with reduced intraoperative hemorrhage. He experienced postoperative intra-abdominal wall hemorrhage, which was successfully managed with red cell concentrates transfusion and administration of recombinant activated factor VII. Laparoscopic hepatectomy can be applied for hemophilia patients with high titer inhibitors.

• Authors: Tatsuo Matsuda, Yuzo Umeda, Kazuhiro Yoshida, Tadakazu Matsuda, Masatoshi Uno, Masaya Abe, Noboru Asada, Yoshinobu Maeda, Takahito Yagi, Toshiyoshi Fujiwara
• Journal: Acta medica Okayama (Acta Med Okayama) Vol. 75 Issue 2 Pg. 199-204 (Apr 2021) ISSN: 0386-300X [Print] Japan
• PMID: 33953426 (Publication Type: Case Reports)

Chemical References

• Factor VIII

Topics

• Carcinoma, Hepatocellular (surgery)
• Factor VIII
• Hemophilia A (complications)
• Hepatectomy (methods)
• Humans
• Laparoscopy (methods)
• Liver Neoplasms (surgery)
• Male
• Middle Aged