Abstract | BACKGROUND:
Clove oil is known for its medicinal properties. The mechanism of anti- cancer properties of Syzygium aromaticum were investigated by mathematical modelling on the genome scale with metabolomics using 1H Nuclear Magnetic Resonance spectroscopy on Raji cells. OBJECTIVES: An integrative analysis correlated the metabolites identified by 1HNMR and genes with the detected pathways. MATERIALS AND METHODS: Raji cells treated with clove oil were collected and sent for 1HNMR spectroscopy and the spectra analyzed by MATLAB and Human Metabolome Database for metabolite identification. Pathway and topology analysis was implemented using the genes and metabolites in the integrative analysis of Metaboanalyst software. RESULTS: CONCLUSION:
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Authors | Mehri Azadi, Fatemeh Alemi, Sedigheh Sadeghi, Maryam Mohammadi, Nowrooz Ali Rahimi, Sako Mirzaie, Farideh Vahabi, Shirin Parvaz, Mohammad Arjmand, Zahra Zamani |
Journal | Iranian journal of biotechnology
(Iran J Biotechnol)
Vol. 18
Issue 3
Pg. e2336
(Jul 2020)
ISSN: 1728-3043 [Print] Iran |
PMID | 33850939
(Publication Type: Journal Article)
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Copyright | Copyright: © 2020 The Author(s); Published by Iranian Journal of Biotechnology. |