[Metronidazole-resistant trichomoniasis and successful therapy following high dosage].

Abstract

A patient is reported who suffered for several months from a Trichomonas vaginalis infection that was resistant to the usual low-dose treatment with 5-nitro-imidazole derivatives. Following various ineffective therapeutic trials, the agent was isolated in order to determine its sensitivity to 5-nitro-imidazole. The resistance of the isolate to metronidazole was confirmed in vitro and in an animal experiment; the patient was therefore treated with high daily doses of metronidazole, 3 x 750 mg orally as well as 2 x 100 mg topically for 14 days. Substitution therapy with zinc was administered in order to normalize the patient's relatively low zinc serum levels. These measures finally led to a clinical cure and elimination of the pathogenic agent. This is the first confirmed case of a metronidazole-resistant Trichomonas vaginalis infection reported in the Federal Republic of Germany.

• Authors: J Weihe, C Metelmann, K Borner, J Meingassner, C E Orfanos
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 39 Issue 4 Pg. 237-9 (Apr 1988) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Metronidazol-resistente Trichomoniasis und erfolgreiche Therapie nach hoher Dosierung.
• PMID: 3384665 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Metronidazole
• Zinc

Topics

• Adult
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Resistance, Microbial
• Female
• Humans
• Metronidazole (administration & dosage)
• Trichomonas Vaginitis (drug therapy)
• Zinc (deficiency)