Abstract | BACKGROUND: METHODS: We conducted qualitative interviews with seven T1DM patients to assess their information needs prior to xenotransplantation. Before the interview, the participants received a model informed consent form for a clinical trial with porcine islet cells transplantation. The interviews were transcribed and analysed using qualitative content analysis. RESULTS: In the interviews, we identified several requirements that are crucial for patients with T1DM in order to consider xenotransplantation as a potential treatment option: therapy-related requirements, professional care and supervision, successful behaviour and attitude management, improving quality of life, and managing control/self-determination challenges. Regarding the informed consent form, several of the participants' questions remained open and should be addressed in more detail. The interviewees stressed the importance of personal consultations. CONCLUSIONS: To become a sustainable therapeutic option, patients especially expected an improved diabetes control and a reduction of diabetes-related burdens. Health-related aspects prove to be pivotal for diabetic patients when considering porcine islet cell transplantation. The use of pigs as source for organ retrievals was not considered as problematic.
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Authors | Johannes Kögel, Sandra Thiersch, Barbara Ludwig, Jochen Seissler, Georg Marckmann |
Journal | BMC medical ethics
(BMC Med Ethics)
Vol. 22
Issue 1
Pg. 37
(04 01 2021)
ISSN: 1472-6939 [Electronic] England |
PMID | 33794874
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Animals
- Diabetes Mellitus, Type 1
(psychology, surgery)
- Humans
- Informed Consent
- Islets of Langerhans Transplantation
(ethics, methods)
- Patient Selection
- Quality of Life
- Swine
- Transplantation, Heterologous
(ethics)
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