An umbilical
metastasis from an internal visceral
malignancy is defined as
Sister Mary Joseph's nodule (SMJN), and, although a rare finding, it is a very poor prognostic
indicator. We describe an interesting case of metastatic
colon cancer with SMJN, emphasizing the significance of this classic finding. A 64-year-old female with a history of stage IV
colon cancer with palliative right
hemicolectomy and left
hepatectomy presented to the hospital with
nausea and abdominal discomfort. A computed tomography (CT) scan of the abdomen was performed, which showed small bowel obstruction secondary to metastatic
tumor mass compressing the duodenum. She refused to undergo any
chemotherapy or endoscopic intervention and was eventually discharged on
hospice care. During the
hospital stay an umbilical ulcerative lesion was also noted, which was violaceous, measuring 4.5 x 4 cm in size, firm in consistency with irregular borders, and tender to touch. Therefore, further history was obtained from the patient about it. Several months ago, she had developed localized swelling around the umbilicus, which gradually enlarged and ulcerated later. She eventually underwent the biopsy of that umbilical lesion, which confirmed it as SMJN with
metastasis from the colonic primary. However, the patient refrained from the surgical intervention of the umbilical lesion. SMJN presents as a palpable periumbilical metastatic mass with diameter usually not exceeding 5 cm in size. It can be variable in color from violaceous to reddish brown. Once discovered, such lesions should be worked up with biopsy and imaging studies such as CT scan of the abdomen, as the nodule may be indicative of underlying
malignancy or
cancer recurrence. Its presence indicates a poor prognosis, with average survival time after diagnosis of SMJN of 10 months.