Prognostic and pharmacologic value of cystatin SN for chronic rhinosinusitis with nasal polyps.

Abstract

BACKGROUND:

Integrated care pathways improve the management of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The application of integrated care pathways requires development of endotype-based biomarkers to stratify patients. The value of cytokines and markers induced by cytokines for the management of CRSwNP is largely unknown.

OBJECTIVES:

Our aim was to determine the prognostic and pharmacologic value of type 2, non-type 2 cytokines, and markers associated with type 2 inflammation, including CCL26, periostin, and cystatin SN, in nasal secretions for CRSwNP.

METHODS:

This retrospective study assigned 151 patients with CRSwNP to the discovery and validation phases. Concentrations of cytokines, CCL26, periostin, and cystatin SN in nasal secretions were determined by using Luminex and ELISA. Predictive significance was assessed with receiver-operating characteristic curves. Survival analysis was performed by using Kaplan-Meier curves and Cox regression models.

RESULTS:

Cystatin SN was an independent predictor of the uncontrolled status of CRSwNP over a 2-year follow-up after adjustment for other risk factors (hazard ratio = 1.168 and 1.132 in the discovery and validation phases, respectively; both P < .001). Patients with high cystatin SN concentrations presented with a faster onset and higher rate of uncontrolled status than did those with low levels (P < .001). Enhanced medical treatment for patients with high cystatin SN levels postponed the uncontrolled status in the discovery (P = .016) and validation (P = .002) phases but did not completely abolish it by the end of the follow-up.

CONCLUSION:

Cystatin SN levels in nasal secretions hold strong prognostic value and can facilitate medical instructions for managing CRSwNP.

• Authors: Di Wu, Bing Yan, Yang Wang, Chengshuo Wang, Luo Zhang
• Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 148 Issue 2 Pg. 450-460 (08 2021) ISSN: 1097-6825 [Electronic] United States
• PMID: 33675819 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• CST1 protein, human
• Salivary Cystatins

Topics

• Adult
• Biomarkers (metabolism)
• Chronic Disease
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Mucus (immunology, metabolism)
• Nasal Polyps (diagnosis, drug therapy, immunology, metabolism)
• Prognosis
• Retrospective Studies
• Rhinitis (diagnosis, drug therapy, immunology, metabolism)
• Salivary Cystatins (immunology, metabolism)
• Sinusitis (diagnosis, drug therapy, immunology, metabolism)