Imipenem/Cilastatin/Relebactam: A Review in Gram-Negative Bacterial Infections.

Abstract

Imipenem/cilastatin/relebactam (Recarbrio™) is an intravenously administered combination of the carbapenem imipenem, the renal dehydropeptidase-I inhibitor cilastatin, and the novel β-lactamase inhibitor relebactam. Relebactam is a potent inhibitor of class A and class C β-lactamases, conferring imipenem activity against many imipenem-nonsusceptible strains. Imipenem/cilastatin/relebactam is approved in the USA and EU for the treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) in adults and other gram-negative infections, including complicated urinary tract infections (cUTIs) [including pyelonephritis] and complicated intra-abdominal infections (cIAIs), in adults with limited or no alternative treatment options. In pivotal phase II and III trials, imipenem/cilastatin/relebactam was noninferior to piperacillin/tazobactam in patients with HABP/VABP and to imipenem/cilastatin in patients with cUTIs and cIAIs. It was also effective in imipenem-nonsusceptible infections. Imipenem/cilastatin/relebactam was generally well tolerated, with a safety profile consistent with that of imipenem/cilastatin. Available evidence indicates that imipenem/cilastatin/relebactam is an effective and generally well tolerated option for gram-negative infections in adults, including critically ill and/or high-risk patients, and a potential therapy for infections caused by carbapenem-resistant pathogens.

• Authors: Young-A Heo
• Journal: Drugs (Drugs) Vol. 81 Issue 3 Pg. 377-388 (Feb 2021) ISSN: 1179-1950 [Electronic] New Zealand
• PMID: 33630278 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Azabicyclo Compounds
• Drug Combinations
• beta-Lactamase Inhibitors
• imipenem, cilastatin and relebactam
• Cilastatin
• Imipenem
• beta-Lactamases

Topics

• Anti-Bacterial Agents (administration & dosage, pharmacology)
• Azabicyclo Compounds (administration & dosage, pharmacology)
• Cilastatin (administration & dosage, pharmacology)
• Drug Combinations
• Gram-Negative Bacterial Infections (drug therapy, metabolism)
• Humans
• Imipenem (administration & dosage, pharmacology)
• Injections, Intravenous
• beta-Lactamase Inhibitors (administration & dosage, pharmacology)
• beta-Lactamases (metabolism)