Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain.

Abstract

AIM:

To validate neuroprotective effect of pectin against neuropathic pain in diabetic rodents.

MATERIAL AND METHOD:

Pectin was isolated and characterised from different sources to validate its neuroprotective effect against T2DM associated neuropathic pain. The antioxidant activity of pectins was done by the DPPH method. Type-2 diabetes mellitus (T2DM) was induced in Wistar albino rats by high-fat diet and high-fat emulsion feeding for 2 weeks followed by a single i.p. of Sterptozotocin in 3rd week. The animals were grouped as positive control and Citrus sinensis (L.) Osbeck peel pectin (CSL-OP) as test group and treated for the next 4 weeks. Body weight and blood glucose were measured up to 8 weeks; however, behavioural assessment was done at the end of 5th to 8th week.

RESULT:

CSL-OP restored the reduced body weight and elevated blood glucose with increased pain threshold and improved walking performance.

CONCLUSION:

CSL-OP prevented progression of early diabetic neuropathy with anti-oxidant activity.

• Authors: Rajnish Srivastava, Laxmi Tripathi, Sudhansu Ranjan Swain, Jagan Singh
• Journal: Archives of physiology and biochemistry (Arch Physiol Biochem) Vol. 129 Issue 4 Pg. 901-912 (Dec 2023) ISSN: 1744-4160 [Electronic] England
• PMID: 33618606 (Publication Type: Journal Article)

Chemical References

• Pectins
• Blood Glucose
• Neuroprotective Agents
• Antioxidants

Topics

• Rats
• Animals
• Hyperalgesia (drug therapy, etiology)
• Diabetic Neuropathies (drug therapy, prevention & control, chemically induced)
• Pectins (adverse effects)
• Blood Glucose
• Neuroprotective Agents
• Diabetes Mellitus, Experimental (chemically induced)
• Rats, Wistar
• Diabetes Mellitus, Type 2 (complications)
• Antioxidants (adverse effects)
• Neuralgia (drug therapy, prevention & control)
• Body Weight