Abstract | BACKGROUND AND AIMS: The reported hepatotoxicity of methotrexate underlines the need for a repeated non-invasive and reliable evaluation of liver fibrosis. We estimated, using a non-invasive strategy, the prevalence of significant liver fibrosis in patients treated by methotrexate and the predictors of significant fibrosis (fibrosis≥F2). METHODS:
Fibrosis was prospectively evaluated using 9 non-invasive tests in consecutive patients with psoriasis, rheumatoid arthritis, or Crohn's disease. Significant fibrosis was assessed without liver biopsy by defining a "specific method" (result given by the majority of the tests) and a "sensitive method" (at least one test indicating a stage≥F2). RESULTS: One hundred and thirty-one patients (66 Psoriasis, 40 rheumatoid arthritis, and 25 Crohn's disease) were enrolled, including 83 receiving methotrexate. Seven tests were performed on average per patient, with a complete concordance in 75% of cases. Fibroscan® was interpretable in only 61% of patients. The best performances (AUROC>0.9) for predicting significant fibrosis were obtained by tests dedicated to steatohepatitis (FibroMeter NAFLD, NFS and FPI). The prevalence of fibrosis≥F2 according to the "specific" or the "sensitive" assessment of fibrosis was 10% and 28%, respectively. Methotrexate exposure did not influence the fibrosis stage. Factors independently associated with significant fibrosis according our "sensitive method" were age, male gender, and metabolic syndrome. CONCLUSION: We provided a non-invasive approach for identifying liver fibrosis≥F2 by using 8 biochemical tests and Fibroscan®. In this population, the risk of significant fibrosis was related to age, male gender, and presence of metabolic syndrome, but was not influenced by methotrexate.
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Authors | Jean-Paul Cervoni, Blandine Alby-Lepresle, Delphine Weil, Peng Zhong, François Aubin, Daniel Wendling, Eric Toussirot, Lucine Vuitton, Franck Carbonnel, Raphaële Blondet, Thierry Thévenot, Paul Calès, Elisabeth Monnet, Vincent Di Martino |
Journal | Clinics and research in hepatology and gastroenterology
(Clin Res Hepatol Gastroenterol)
2020 Jan-Jun
Vol. 44S
Pg. 100003
ISSN: 2210-741X [Electronic] France |
PMID | 33602481
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
Chemical References |
- Immunosuppressive Agents
- Methotrexate
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Topics |
- Age Factors
- Arthritis, Rheumatoid
(drug therapy)
- Crohn Disease
(drug therapy)
- Elasticity Imaging Techniques
- Female
- Humans
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Liver Cirrhosis
(chemically induced, diagnosis, epidemiology)
- Male
- Methotrexate
(adverse effects, therapeutic use)
- Middle Aged
- Prevalence
- Prospective Studies
- Psoriasis
(drug therapy)
- Sex Factors
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