This study aimed to investigate the protective effect of
Xinmailong injection on rats with
myocardial infarction. Thirty-six rats were induced
myocardial infarction by operation, and six underwent
sham operation. The
myocardial infarction rats were randomly divided into three groups, 12 in each, and administered
intraperitoneal injection of
Xinmailong 5 mg/(kg·d),
sodium creatine phosphate 80 mg/(kg·d), or
normal saline as control respectively for 14 days. When the treatments were completed, the hemodynamic parameters of the rats were observed, and blood samples were taken to examine blood routine, blood coagulation index, liver and kidney function, inflammatory index, myocardial marker, thrombo-elastography, and other indicators. The morphology of cardiomyocytes was observed through light microscopy, and the microstructure of the myocardial cells was observed under electron microscope. No significant difference was found in blood routine, liver and kidney function, and blood coagulation index between the
Xinmailong and
sodium creatine phosphate groups compared with the saline control group. However, the inflammatory index and levels of myocardial markers were significantly decreased, and cardiac function was significantly improved. In terms of the morphology of myocardial cells, the
Xinmailong group was similar to the
sodium creatine phosphate group, the myocardial cell membrane was protected, and myocardial cell damage was reduced. In conclusion,
Xinmailong is safe and had anti-inflammatory, heart-improving, and myocardial-protective effects. Its effectiveness is not inferior to that of
sodium creatine phosphate.