Abstract |
Intravenous (IV) iron is the therapy of choice when oral iron is ineffective or poorly tolerated, yet use has been limited by fears of hypersensitivity reactions (HSRs). Newer formulations that bind iron more tightly and release it more slowly have made the risk of serious or severe HSRs very low. One such formulation, ferric derisomaltose, has been approved in the United States for delivery of 1000 mg iron in a single IV infusion. Ferric derisomaltose rapidly repletes iron parameters with low rates of serious or severe HSRs. Single-infusion iron repletion offers convenience, eliminates adherence concerns, and reduces healthcare resource utilization.
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Authors | Michael Auerbach, David Henry, Thomas G DeLoughery |
Journal | American journal of hematology
(Am J Hematol)
Vol. 96
Issue 6
Pg. 727-734
(06 01 2021)
ISSN: 1096-8652 [Electronic] United States |
PMID | 33580972
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2021 The Authors. American Journal of Hematology published by Wiley Periodicals LLC. |
Chemical References |
- Biomarkers
- Disaccharides
- Ferric Compounds
- Hemoglobins
- iron isomaltoside 1000
- ferric derisomaltose
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Topics |
- Anemia, Iron-Deficiency
(drug therapy)
- Biomarkers
- Cardiovascular Diseases
(chemically induced)
- Diagnosis, Differential
- Disaccharides
(administration & dosage, adverse effects, chemistry, therapeutic use)
- Drug Costs
- Drug Hypersensitivity
(diagnosis, etiology)
- Fatigue
(chemically induced)
- Female
- Ferric Compounds
(administration & dosage, adverse effects, chemistry, therapeutic use)
- Flushing
(chemically induced, diagnosis)
- Forecasting
- Hemoglobins
(analysis)
- Humans
- Hypophosphatemia
(blood, chemically induced)
- Infusions, Intravenous
- Male
- Multicenter Studies as Topic
- Pregnancy
- Pregnancy Complications, Hematologic
(drug therapy)
- Prospective Studies
- Randomized Controlled Trials as Topic
- United States
- United States Food and Drug Administration
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