Retrospective German claims data study on initial treatment of bladder carcinoma (BCa) by transurethral bladder resection (TURB): a comparative analysis of costs using standard white light- (WL-) vs. blue light- (BL-) TURB.

Abstract

PURPOSE:

Photodynamic diagnosis using hexaminolevulinate (HAL)-guided BL-TURB may reduce the recurrence risk in non-muscle invasive BCa compared to standard WL-TURB due to more sensitive tumor detection. The impact of the initial use of WL- vs. BL-TURB on follow-up costs was evaluated in this real-world data analysis.

METHODS:

Anonymous claims data of German statutory health insurances (GKV) from 2011 to 2016 were analyzed in a primary and adjusted study population. Selection criteria included five quarters before enrolment, one index quarter (InQ) of initial TURB and BCa diagnosis, either within two years for the primary analysis or within four years for the adjusted analysis, and a follow-up period (FU) of either eleven or three quarters, respectively.

RESULTS:

In the primary analysis (n = 2331), cystectomy was identified as an important cost driver masking potential differences between cohorts. Therefore, patients undergoing cystectomy (InQ + FU) were excluded from the adjusted study population of n = 4541 patients (WL: 79%; BL: 21%). Mean total costs of BL-TURB were initially comparable to WL-TURB (WL: EUR 4534 vs. BL: EUR 4543) and tended to be lower compared to WL-TURB in the first two quarters of FU. After one year (3rd FU quarter), costs equalized. Considering total FU, mean costs of BL-TURB were significantly lower compared to WL-TURB (WL: EUR 7073 vs BL: EUR 6431; p = 0.045).

CONCLUSION:

This retrospective analysis of healthcare claims data highlights the comparability of costs between BL-TURB and WL-TURB.

• Authors: Tilman Todenhöfer, Moritz Maas, Miriam Ketz, Nils Kossack, Christiane Colling, Bryan Qvick, Arnulf Stenzl
• Journal: World journal of urology (World J Urol) Vol. 39 Issue 8 Pg. 2953-2960 (Aug 2021) ISSN: 1433-8726 [Electronic] Germany
• PMID: 33569642 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s).

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid
• 5-aminolevulinic acid hexyl ester

Topics

• Aged
• Aminolevulinic Acid (analogs & derivatives, pharmacology)
• Carcinoma (diagnostic imaging, epidemiology, pathology, surgery)
• Cystectomy (adverse effects, economics, methods)
• Cystoscopy (methods)
• Female
• Germany (epidemiology)
• Health Care Costs (statistics & numerical data)
• Health Services Research
• Humans
• Insurance Claim Review
• Male
• Neoplasm Recurrence, Local (diagnosis, epidemiology)
• Photosensitizing Agents (pharmacology)
• Retrospective Studies
• Urinary Bladder Neoplasms (diagnostic imaging, epidemiology, pathology, surgery)