The Effect of HCV Eradication after Direct-Acting Antiviral Agents on Hepatic Steatosis: A Prospective Observational Study.

Abstract

BACKGROUND AND AIM:

Eradication of hepatitis C virus (HCV) by direct-acting-antiviral- agents (DAAs) was followed by fibrosis regression, but little is available about hepatic steatosis changes after DAAs. The aim of this work was to assess the prevalence of hepatic steatosis among HCV Egyptian patients and the long term changes occuring after viral eradication.

METHODS:

This prospective cohort study included 150 HCV patients with significant fibrosis. They were examined by Transient elastography to evaluate liver stiffness measurement (LSM) and hepatic steatosis before treatment, at SVR12 and 1 year after the end of therapy.

RESULTS:

LSM showed a significant positive correlation to pretreatment of hepatic steatosis. LSM significantly decreased and hepatic steatosis significantly increased both at SVR12 and one year after DAAs. Patients with steatosis showed significantly higher median LSM and controlled attenuation parameter (CAP) values at: baseline, SVR12, and one year after therapy. Also, the pretreatment steatosis and body mass index (BMI) had a significant negative correlation with fibrosis regression one year after therapy in all studied groups.

CONCLUSION:

Hepatic steatosis is common in HCV Egyptian patients and increases after HCV eradication with DAAs. BMI and CAP values are negatively correlated to hepatic fibrosis regression and positively correlated to steatosis progression one year after DAAs. So, HCV patients with hepatic steatosis may need close follow up for atherosclerotic and HCC risk after DAAs, especially if they are overweight.

• Authors: Hanan Soliman, Dina Ziada, Manal Hamisa, Rehab Badawi, Nehad Hawash, Marwa Salama, Sherief Abd-Elsalam
• Journal: Endocrine, metabolic & immune disorders drug targets (Endocr Metab Immune Disord Drug Targets) Vol. 22 Issue 1 Pg. 100-107 ( 2022) ISSN: 2212-3873 [Electronic] United Arab Emirates
• PMID: 33550979 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Antiviral Agents

Topics

• Adult
• Antiviral Agents (pharmacology, therapeutic use)
• Carcinoma, Hepatocellular (epidemiology, etiology)
• Egypt (epidemiology)
• Elasticity Imaging Techniques
• Fatty Liver (diagnosis, drug therapy, epidemiology, virology)
• Female
• Hepacivirus (drug effects, physiology)
• Hepatitis C (complications, diagnosis, drug therapy, epidemiology)
• Humans
• Liver Cirrhosis (diagnosis, drug therapy, epidemiology, virology)
• Liver Neoplasms (epidemiology, etiology)
• Male
• Middle Aged
• Prognosis
• Prospective Studies
• Risk Factors
• Treatment Outcome