Abstract | OBJECTIVES: METHODS: A cross-sectional study of 120 newly diagnosed SSc patients with the onset of less than 4 years were evaluated on clinical characteristics and hand radiographs. Acro-osteolysis was graded on a 0-4-point scale based on the severity and the patients were subdivided into mild, moderate and severe. RESULTS: Among all SSc patients enrolled, 62.5% were females, 56.1% dcSSc and the vast majority of them (84.1%) were positive for anti-topoisomerase I antibody (anti- topo I). The mean disease duration was 2.0±1.3 years. Acro-osteolysis was noted in 77 patients with a prevalence of 64.1% (95%CI 54.9-72.7), of which 16.7% were defined as severe acro-osteolysis. Logistic regression analysis revealed that acro-osteolysis was positively associated with anti- topo I (OR 13.96), hand deformity (OR 3.81) and dysphagia (OR 6.66), but negatively associated with oedematous skin (OR 0.05). Analysis stratified by severity of acro-osteolysis showed significant differences between subgroup in terms of the presence of digital gangrene (p=0.02), ischaemic ulcer (p=0.001), oedematous skin (p=0.001), and hand deformities (p=0.01). CONCLUSIONS:
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Authors | Aornnicha Sakchaikul, Prathana Chowchuen, Chingching Foocharoen, Punthip Thammaroj |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2021 Sep-Oct
Vol. 39
Issue 5
Pg. 1093-1098
ISSN: 0392-856X [Print] Italy |
PMID | 33427611
(Publication Type: Journal Article)
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Topics |
- Acro-Osteolysis
(diagnostic imaging, epidemiology)
- Cross-Sectional Studies
- Female
- Humans
- Prevalence
- Scleroderma, Diffuse
(complications, diagnostic imaging, epidemiology)
- Scleroderma, Systemic
(complications, epidemiology)
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