Abstract | BACKGROUND: METHODS:
SCO-792, an orally available enteropeptidase inhibitor, was administered [0.03% and 0.06% (w/w) in the diet] to 20-week-old SHC rats showing albuminuria and progressive decline in glomerular filtration rate (GFR) for five weeks. The effects of SCO-792 and the contribution of amino acids to these effects were evaluated. RESULTS: CONCLUSIONS:
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Authors | Yuko Katayama, Jun Sugama, Tomohisa Suzuki, Yoshimasa Ishimura, Akihiro Kobayashi, Yusuke Moritoh, Masanori Watanabe |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 36
Issue 4
Pg. 631-640
(03 29 2021)
ISSN: 1460-2385 [Electronic] England |
PMID | 33351150
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. |
Chemical References |
- Enzyme Inhibitors
- Enteropeptidase
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Topics |
- Albuminuria
(drug therapy, etiology, pathology)
- Animals
- Enteropeptidase
(antagonists & inhibitors)
- Enzyme Inhibitors
(pharmacology)
- Fibrosis
(drug therapy, etiology, pathology)
- Glomerular Filtration Rate
- Hypercholesterolemia
(physiopathology)
- Kidney Diseases
(drug therapy, etiology, pathology)
- Male
- Rats
- Renal Insufficiency, Chronic
(complications)
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