A multicenter study of the safety and efficacy of naproxen: analysis of blood pressure.

Abstract

A multicenter study was conducted to determine safety and efficacy of naproxen, 500 mg twice daily, administered for 4 weeks to osteoarthritis (OA) patients. OA symptoms improved in the study population. The study population included 97 patients, 43 of whom were 65 years of age or older. Forty-four of the 97 patients had a history of hypertension; 42 of these took antihypertensive medication before and during the study. Baseline blood pressure (BP) was measured in most patients while they were receiving their prior nonsteroidal antiinflammatory drug (NSAID) therapy; from that baseline, no increase in BP was seen in the hypertensive or normotensive patients after 4 weeks of naproxen therapy. In patients whose BP was controlled by antihypertensive agents, BP remained under control during naproxen therapy.

• Authors: M A Goldberg
• Journal: Seminars in arthritis and rheumatism (Semin Arthritis Rheum) Vol. 17 Issue 3 Suppl 2 Pg. 23-8 (Feb 1988) ISSN: 0049-0172 [Print] United States
• PMID: 3334107 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Naproxen

Topics

• Adult
• Aged
• Blood Pressure (drug effects)
• Humans
• Hypertension (complications)
• Middle Aged
• Multicenter Studies as Topic
• Naproxen (administration & dosage, adverse effects, therapeutic use)
• Osteoarthritis (drug therapy)
• Safety