Abstract | INTRODUCTION:
Pain related to cancer, and its treatment, is common, may severely impair quality of life, and imposes a burden on patients, their families and caregivers, and society. Cancer-related pain is often challenging to manage, with limitations of analgesic drugs including incomplete efficacy and dose-related adverse effects. OBJECTIVES: METHODS: Using a predefined literature search strategy, trials-comparing the combination of 2 or more nonopioid analgesics with at least one of the combination's individual components-will be searched on the PubMed and EMBASE databases from their inception until the date the searches are run. Outcomes will include pain intensity or relief, adverse effects, and concomitant opioid consumption. RESULTS/CONCLUSIONS: This review is expected to synthesize available evidence describing the efficacy and safety of nonopioid analgesic combinations for cancer-related pain. Furthermore, a review of this literature will serve to identify future research goals that would advance our knowledge in this area.
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Authors | Gursharan Sohi, Augusto Caraceni, Dwight E Moulin, Camilla Zimmermann, Leonie Herx, Ian Gilron |
Journal | Pain reports
(Pain Rep)
2020 Nov-Dec
Vol. 5
Issue 6
Pg. e856
ISSN: 2471-2531 [Electronic] United States |
PMID | 33134752
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. |