ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved.

Abstract

Substantial human and animal studies support the beneficial effects of ω-3 polyunsaturated fatty acids (PUFAs) on colonic inflammation and colorectal cancer (CRC). However, there are inconsistent results, which have shown that ω-3 PUFAs have no effect or even detrimental effects, making it difficult to effectively implement ω-3 PUFAs for disease prevention. A better understanding of the molecular mechanisms for the anti-inflammatory and anticancer effects of ω-3 PUFAs will help to clarify their potential health-promoting effects, provide a scientific base for cautions for their use, and establish dietary recommendations. In this review, we summarize recent studies of ω-3 PUFAs on colonic inflammation and CRC and discuss the potential roles of ω-3 PUFA-metabolizing enzymes, notably the cytochrome P450 monooxygenases, in mediating the actions of ω-3 PUFAs.

• Authors: Maolin Tu, Weicang Wang, Guodong Zhang, Bruce D Hammock
• Journal: Nutrients (Nutrients) Vol. 12 Issue 11 (Oct 28 2020) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 33126566 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents
• Fatty Acids, Omega-3
• Cytochrome P-450 Enzyme System
• Mixed Function Oxygenases
• Epoxide Hydrolases

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antineoplastic Agents (pharmacology)
• Colitis (prevention & control)
• Colon (drug effects)
• Colorectal Neoplasms (prevention & control)
• Cytochrome P-450 Enzyme System (metabolism)
• Epoxide Hydrolases (metabolism)
• Fatty Acids, Omega-3 (pharmacology)
• Humans
• Mixed Function Oxygenases (metabolism)