Abstract | OBJECTIVE: METHODS: This randomized clinical trial study included 92 children with rolandic epilepsy aged 4-12 years referred to the Pediatric Neurology Clinic at Imam Hossein Hospital, Isfahan, Iran, from April 2019 to January 2020. Patients were selected consecutively and randomly assigned to two study groups ( levetiracetam and carbamazepine groups). Patients were followed and revisited every 2 months for 6 months after starting the medication. The frequency and duration of seizure attacks and drug side effects were recorded before treatment and in bi-monthly visits. Data were analyzed by SPSS software Version 24 using Mann-Whitney U- test and Friedman test. FINDINGS: In our study, the seizure frequency decrease was not significantly different between the two groups; however, patients in both groups showed significantly lower seizure frequency in 2, 4, and 6 months of follow-up compared to starting time. After a follow-up for 6 months, one out of 47 (2.1%) patients using levetiracetam showed intolerance, resulting in changing the medication. In addition, two out of 48 (4.1%) patients in the carbamazepine group had skin rashes. No significant changes had been reported regarding the duration of seizure attacks in both groups after treatment. CONCLUSION: This study showed encouraging results for using levetiracetam, with acceptable results and fewer side effects for the treatment of children with BCECTS in Iran.
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Authors | Parisa Ahadi, Jafar Nasiri, Mohammad Reza Ghazavi, Toktam Mosavian, Vahid Mansouri |
Journal | Journal of research in pharmacy practice
(J Res Pharm Pract)
2020 Apr-Jun
Vol. 9
Issue 2
Pg. 68-72
ISSN: 2319-9644 [Print] India |
PMID | 33102380
(Publication Type: Journal Article)
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Copyright | Copyright: © 2020 Journal of Research in Pharmacy Practice. |