Filgrastim associations with CAR T-cell therapy.

Abstract

Little is known about the benefits and risks of myeloid growth factor administration after chimeric antigen receptor (CAR) T-cell therapy for diffuse large B-cell lymphoma (DLBCL). We present a retrospective analysis among 22 relapsed/refractory DLBCL patients who received CAR T-cell therapy with axicabtagene ciloleucel. Filgrastim was administered by physician discretion to seven patients (31.8%), and the median duration of neutropenia after lymphodepleting therapy was significantly shorter for those patients who received filgrastim (5 vs 15 days, P = .016). Five patients (22.7%) developed infection in the 30 days post-CAR T-cell therapy with three patients being Grade 3 or higher. There was no difference in the incidence and severity of infection based on filgrastim use (P = .274, P = .138). Among the seven patients that received filgrastim, six patients (85.7%) and four patients (57.1%) had evidence of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), respectively. Among the 15 patients that did not receive filgrastim, 8 patients (53.3%) and 7 patients (46.7%) had evidence of CRS and ICANS, respectively. There was no significant difference in the incidence of developing CRS or ICANS between the group of patients that received filgrastim and those that did not (P = .193, P = .647). However, there was a significant increase in the severity of CRS for patients that received filgrastim compared to those that did not (P = .042). Filgrastim administration after CAR T-cell therapy may lead to an increase in severity of CRS without decreasing infection rates.

• Authors: Daria Gaut, Kevin Tang, Myung Shin Sim, Tuyen Duong, Patricia Young, Joshua Sasine
• Journal: International journal of cancer (Int J Cancer) Vol. 148 Issue 5 Pg. 1192-1196 (03 01 2021) ISSN: 1097-0215 [Electronic] United States
• PMID: 33091961 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: © 2020 Union for International Cancer Control.

Chemical References

• Receptors, Chimeric Antigen
• Filgrastim

Topics

• Aged
• Cytokine Release Syndrome (epidemiology)
• Female
• Filgrastim (adverse effects)
• Humans
• Immunotherapy, Adoptive (methods)
• Lymphoma, Large B-Cell, Diffuse (immunology, therapy)
• Male
• Middle Aged
• Neurotoxicity Syndromes (epidemiology)
• Neutropenia (prevention & control)
• Receptors, Chimeric Antigen (immunology)
• Retrospective Studies