The combined effects of probiotics and restricted calorie diet on the anthropometric indices, eating behavior, and hormone levels of obese women with food addiction: a randomized clinical trial.

Abstract

BACKGROUND AND AIM:

Food addiction (FA) is an important contributor to obesity. Alterations in gut microbiota (GM) diversity and composition have also been proposed to play a pivotal role in obesity pathogenesis. This trial aimed to assess the effects of probiotic supplementation on the anthropometric indices, eating behavior, and hormone levels of obese women with FA.

METHODS:

This randomized, double-blind, placebo-controlled clinical trial was conducted among obese women with FA. Participants (n = 62) received a restricted calorie diet (RCD) plus either probiotic, or placebo for 12 weeks. Anthropometric measurements, biochemical markers, eating behavior and appetite were assessed during the study period.

RESULTS:

Probiotics administration significantly reduced weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percentage (BFP), and trunk fat percentage (TFP) compared to the placebo group (p < 0.001). Also, a significant improvement was observed in eating behavior in the probiotic group compared to the placebo group (p < 0.001).Serum levels of oxytocin increased and NPY decreased significantly in the probiotic group compared to the placebo group (p = 0.02, p = 0.002, respectively). Moreover, leptin level significantly decreased in the probiotic group compared to the baseline values (p < 0.001), while probiotics did not cause a greater significant reduction in leptin level, compared to the placebo group.

CONCLUSION:

Multi-probiotic supplementation may have beneficial effects on anthropometric indices, eating behavior, and some appetite-regulating hormones in obese women with FA.Trial registration: Iranian Registry of Clinical Trials identifier: IRCT20131228015968N5.

• Authors: Elham Narmaki, Mohaddeseh Borazjani, Asal Ataie-Jafari, Nastaran Hariri, Azita Hekmat Doost, Mostafa Qorbani, Atoosa Saidpour
• Journal: Nutritional neuroscience (Nutr Neurosci) Vol. 25 Issue 5 Pg. 963-975 (May 2022) ISSN: 1476-8305 [Electronic] England
• PMID: 33054635 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Leptin

Topics

• Body Mass Index
• Double-Blind Method
• Energy Intake
• Feeding Behavior
• Female
• Food Addiction
• Humans
• Iran
• Leptin
• Obesity (complications, therapy)
• Probiotics (therapeutic use)