Fast-acting γδ T-cell subpopulation and protective immunity against infections.

Abstract

Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathogens during infections. Recent seminal studies in non-human primate models have demonstrated that the unique HMBPP-specific Vγ2Vδ2 T cells are fast-acting, multi-functional, and protective during infections. This article reviews the recent seminal observations of Vγ2Vδ2 T cells in protective mechanisms against tuberculosis and other infections.

• Authors: Ling Shen, Dan Huang, Arwa Qaqish, James Frencher, Rui Yang, Hongbo Shen, Zheng W Chen
• Journal: Immunological reviews (Immunol Rev) Vol. 298 Issue 1 Pg. 254-263 (11 2020) ISSN: 1600-065X [Electronic] England
• PMID: 33037700 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Receptors, Antigen, T-Cell, gamma-delta

Topics

• Animals
• Mycobacterium tuberculosis
• Receptors, Antigen, T-Cell, gamma-delta
• T-Lymphocytes
• Tuberculosis