Olanzapine is an atypical
antipsychotic drug that has been increasingly used for treatment in
schizophrenia. It has been observed that
olanzapine responses in
schizophrenia patients vary individually, but the reason has not been elucidated. In the study, we aimed to comprehensively explore the relationships between
olanzapine responses and genetic polymorphisms of
drug metabolizing
enzymes, transporters and target receptors, and so as to interpret the reason of good and poor responses of
olanzapine. A total of 241 Chinese Han
paranoid schizophrenia who treated with
olanzapine alone for 4 weeks were recruited. The positive and negative symptom scale (PANSS) was used to evaluate the efficacy of
olanzapine. The genetic polymorphisms were detected by improved multiple
ligase detection reaction (iMLDR). Multivariate logistic regression analysis suggested that the genetic polymorphisms of
CYP1A2 rs762551, UGT1A4 rs2011425, ABCB1 rs1045642, DRD2 rs1799732 and rs1799978, 5-HTR2A rs6311 were significantly associated with
olanzapine response. Multifactor dimensionality reduction (MDR) analysis showed that there was a negative interaction between
CYP1A2 rs762551, ABCB1 rs1045642, DRD2 rs1799978, 5-HTR2A rs6311 and the interaction model was the optimal model. Our findings could partially explain the different
olanzapine outcome and provided evidence for clarifying the predictive indicators of
olanzapine response in further.