Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study.

Abstract

BACKGROUND:

Although many epidemiological studies have reported the preventive effects of soy products and isoflavones on prostate cancer, our previous studies reported that the association between soy and isoflavones and prostate cancer incidence differed according to stage. It is more important to identify modifiable risk factors related to lethal prostate cancer. Here, we investigated the association between soy, soy products and isoflavones intake and prostate cancer mortality, in a prospective study in Japan.

METHODS:

We conducted a population-based prospective study in 43 580 Japanese men with no history of cancer or cardiovascular disease (aged 45-74 years). Participants completed a validated questionnaire which included 138 food items. We followed participants from 1995 to 2016. Hazard ratios (HRs) and 95% confidence intervals (CIs) of prostate cancer mortality were calculated according to quintiles of soy products and isoflavones intake, using Cox hazard proportional hazards regression.

RESULTS:

During 16.9 years follow-up, we registered 221 deaths from prostate cancer. Isoflavones and soy products intake was associated with an increased risk of prostate cancer death, with multivariate HRQ5 vs. Q1=1.39, 95% CI = 0.87-2.20, p for trend = 0.04 for isoflavones and multivariate HRQ5 vs. Q1=1.76, 95% CI = 1.10-2.82, p for trend = 0.04 for soy food.

CONCLUSIONS:

Our study suggested that high intake of soy and isoflavones might increase the risk of prostate cancer mortality.

• Authors: Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Manami Inoue, Shoichiro Tsugane, Japan Public Health Center-based Prospective Study Group
• Journal: International journal of epidemiology (Int J Epidemiol) Vol. 49 Issue 5 Pg. 1553-1561 (10 01 2020) ISSN: 1464-3685 [Electronic] England
• PMID: 32968784 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2020; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

Chemical References

• Isoflavones

Topics

• Aged
• Diet
• Humans
• Isoflavones
• Japan (epidemiology)
• Male
• Middle Aged
• Prospective Studies
• Prostatic Neoplasms (epidemiology)
• Public Health
• Risk Factors
• Soy Foods
• Surveys and Questionnaires