Higher blood glucose impairs cardiac autonomic modulation in fasting and after carbohydrate overload in adults.

Abstract

This study aimed to assess whether the blood glucose levels influence cardiac autonomic modulation under fasting and after carbohydrate overload conditions. Participants (n = 108) were separated into lower blood glucose and higher blood glucose groups, based on the median (90.5 mg·dL-1) of fasting glucose assessed. The SD2, SDNN, LF indices, and LF/HF increased, and HF decreased after dextrose overload compared with fasting (p < 0.05). Body mass (78.9 vs 69.7 kg), abdominal circumference (90.2 vs 82.2 cm), systolic (113 vs 108 mm Hg) and diastolic (72 vs 67 mm Hg) blood pressure were higher (p < 0.05) in the higher blood glucose group. Heart rate variability (HRV) indices (SD1: 21.0 vs 26.5; SD2: 76.8: vs 86.1; RMSSD: 28.7 vs 37.5; SDNN: 56.1 vs 62.5 ms; pNN50: 10.6 vs 18.9%, HF: 328.4 vs 506.0; LF: 982.8 vs 1259.0 ms2), and the area under the curve of these indices after dextrose overload were lower in the higher blood glucose group (p < 0.05). Additionally, glycemia after dextrose overload was correlated with HRV indices (ρ = -0.216 to -0.273, p < 0.05). Individuals with higher blood glucose, even in the normality range, showed impairment in the cardiac autonomic modulation both at fasting and after carbohydrate overload. Novelty: Higher fasting blood glucose impairs cardiac autonomic modulation. Carbohydrate overload impairs cardiac autonomic modulation.

• Authors: Caroline Maria Oliveira, Ana Carolina Ghezzi, Lucieli Teresa Cambri
• Journal: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme (Appl Physiol Nutr Metab) Vol. 46 Issue 3 Pg. 221-228 (Mar 2021) ISSN: 1715-5320 [Electronic] Canada
• PMID: 32898425 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Dietary Carbohydrates

Topics

• Adolescent
• Adult
• Autonomic Nervous System (physiology, physiopathology)
• Blood Glucose
• Blood Pressure
• Dietary Carbohydrates (administration & dosage, adverse effects)
• Fasting
• Female
• Heart (physiology, physiopathology)
• Heart Rate
• Humans
• Male
• Young Adult