Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma.

Abstract

Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are noncoding RNAs (ncRNAs) that occupy over 90% of the human genome, and their main function is to directly or indirectly regulate messenger RNA (mRNA) expression and participate in the tumorigenesis and progression of malignances. In particular, some lncRNAs can interact with miRNAs as competing endogenous RNAs (ceRNAs) to modulate mRNA expression. Accordingly, these RNA molecules are interrelated and coordinate to form a dynamic lncRNA-mediated ceRNA regulatory network. Mounting evidence has revealed that lncRNAs that act as ceRNAs are closely related to tumorigenesis. To date, numerous studies have established many different regulatory networks in hepatocellular carcinoma (HCC), and perturbations in these ceRNA interactions may result in the initiation and progression of HCC. Herein, we emphasize recent advances concerning the biological function of lncRNAs as ceRNAs in HCC, with the aim of elucidating the molecular mechanism underlying these HCC-related RNA molecules and providing novel insights into the diagnosis and treatment of HCC.

• Authors: Zhao-Shan Niu, Wen-Hong Wang, Xian-Ning Dong, Li-Mei-Li Tian
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 26 Issue 29 Pg. 4240-4260 (Aug 07 2020) ISSN: 2219-2840 [Electronic] United States
• PMID: 32848331 (Publication Type: Journal Article, Review)
• Copyright: ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

Chemical References

• MicroRNAs
• RNA, Long Noncoding

Topics

• Carcinoma, Hepatocellular (genetics)
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Humans
• Liver Neoplasms (genetics)
• MicroRNAs
• RNA, Long Noncoding (genetics)