Abstract |
Paris Saponin II (PSII) has been regarded as an effective and imperative component isolated from Rhizoma Paridis saponins (RPS) and exhibited strong anti- tumor effects on a variety of cancer. Our results revealed that human non-small lung cancer cell lines NCI-H460 and NCI-H520 were exposed to 1 μM of PSII, which inhibited the proliferation of lung cancer cells and activated apoptosis, autophagy and paraptosis. PSII induced paraptosis-associated cell death prior to apoptosis and autophagy. It induced paraptosis based on ER stress through activation of the JNK pathway. Meanwhile, PSII increased the cytotoxicity of cisplatin through paraptosis-associated pathway. All in all, PSII induced paraptosis based on induction of non-apoptotic cell death, which would be a possible approach to suppress the multi-drug resistant to apoptosis.
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Authors | Shuli Man, Panpan Lv, Jingxia Cui, Furui Liu, Lei Peng, Long Ma, Changxiao Liu, Wenyuan Gao |
Journal | Toxicology and applied pharmacology
(Toxicol Appl Pharmacol)
Vol. 406
Pg. 115206
(11 01 2020)
ISSN: 1096-0333 [Electronic] United States |
PMID | 32835762
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Saponins
- formosanin C
- Diosgenin
- Cisplatin
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Topics |
- Antineoplastic Agents
(pharmacology)
- Autophagy
(drug effects)
- Cell Death
(drug effects)
- Cell Line, Tumor
- Cisplatin
(pharmacology)
- Diosgenin
(analogs & derivatives, pharmacology)
- Endoplasmic Reticulum Stress
(drug effects)
- Humans
- MAP Kinase Signaling System
(drug effects)
- Saponins
(pharmacology)
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