Abstract | BACKGROUND: METHODS: Clinical prognostic parameters and survival data related to PITX1 in breast cancer patients were performed using the bioinformatic analysis including Oncomine, Bc-GenExMiner v4.3, PrognoScan and UCSC Xena. RESULTS: We found that PITX1 gene expression was significantly higher in different histological classification of breast cancer. The Scarff-Bloom-Richardson (SBR) grade, Nottingham prognostic index (NPI), estrogen receptor (ER) negative, epidermal growth factor receptor-2 (HER2) positive, lymph node positive, triple-negative status and basal-like status were positively correlated with PITX1 level, except for patients' age and the progesterone receptor (PR) status. We have found that the increased PITX1 expression correlated with worse relapse-free survival, disease specific survival and overall survival. PITX1 was positively correlated with metastatic relapse-free survival and distant metastasis-free survival. We also confirmed positive correlation between PITX1 and the nucleotide-binding oligomerization domain 2 (NOD2). CONCLUSION: The lower expression of PITX1 was associated with better clinical prognostic parameters and clinical survival in breast cancer according to the bioinformatic analysis.
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Authors | Qiaoyun Wang, Shuai Zhao, Lei Gan, Zhixiang Zhuang |
Journal | Bioscience reports
(Biosci Rep)
Vol. 40
Issue 9
(09 30 2020)
ISSN: 1573-4935 [Electronic] England |
PMID | 32830857
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 The Author(s). |
Chemical References |
- Paired Box Transcription Factors
- homeobox protein PITX1
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Topics |
- Breast Neoplasms
(genetics, mortality, pathology)
- Computational Biology
(methods)
- Databases, Factual
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Paired Box Transcription Factors
(genetics)
- Prognosis
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