Abstract | INTRODUCTION: METHODS: We assessed thyroid function by measuring thyroid stimulation hormone (TSH), fT4, T3, fT3, and rT3 before diet start (baseline) and after 12 weeks on the diet in 53 adult patients with drug-resistant epilepsy. Further, we examined the correlation between the changes in thyroid function during dietary treatment and type of (i) change in seizure frequency, (ii) drugs in use, and (iii) degree of ketosis. RESULTS: After 12 weeks on the diet, we found a significant reduction in T3 and fT3 values (13.4% and 10.6%, respectively) and a significant increase in fT4 values (12.1%) compared with baseline. In addition, there was an insignificant increase in TSH and rT3. These changes were similar in women and men, and there was no correlation to drugs in use ( enzyme-inducing vs. nonenzyme-inducing drugs), changes in seizure frequency, or level of ketosis. CONCLUSION:
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Authors | Ellen Molteberg, Per Medbøe Thorsby, Magnhild Kverneland, Per Ole Iversen, Kaja Kristine Selmer, Karl Otto Nakken, Erik Taubøll |
Journal | Epilepsy & behavior : E&B
(Epilepsy Behav)
Vol. 111
Pg. 107285
(10 2020)
ISSN: 1525-5069 [Electronic] United States |
PMID | 32698106
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Triiodothyronine
- Thyroxine
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Topics |
- Adolescent
- Adult
- Aged
- Diet, High-Protein Low-Carbohydrate
(methods, trends)
- Diet, Ketogenic
(methods, trends)
- Drug Resistant Epilepsy
(blood, diet therapy)
- Female
- Humans
- Ketosis
(blood, chemically induced)
- Male
- Middle Aged
- Prospective Studies
- Thyroid Gland
(metabolism)
- Thyroxine
(blood)
- Triiodothyronine
(blood)
- Young Adult
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