Epilepsy is a common
neurologic disorder, which is efficiently treated with
carbamazepine and
valproic acid. Moreover, Saudi Ministry of Health implemented a new E-system for Poison Control Centers called Awtar to enhance technology utilization in ensuring patients' satisfaction and to improve treatment outcomes. Therefore, we conducted this study to assess appropriateness of indication of requests and therapeutic levels of
carbamazepine and
valproic acid in Tabuk area, North West Saudi Arabia. This is a retrospective observational study conducted in
Poison Control & Forensic Chemistry Center, Tabuk, Saudi Arabia. Patients' data were obtained for years 2018 and 2019. The blood levels of
carbamazepine and
valproic acid were measured by Therapeutic
Drug Monitoring (TDM) Unit. We selected patients treated with either
valproic acid or
carbamazepine alone without any history of
drug allergy. Data of 264 patients were extracted from Awtar E-system. Serum
carbamazepine levels were within therapeutic range in 114 patients (75.50%), above-therapeutic range in 13 patients (8.61%) and sub-therapeutic levels in 24 patients (15.89%). Regarding serum
valproic acid, it is within therapeutic range in 62 patients (54.87%), above-therapeutic range in 11 patients (9.73%) and sub-therapeutic levels in 40 patients (35.40%). In conclusion, this study gives information about partial appropriateness of usage of
carbamazepine and low level of appropriateness of
valproic acid. However, more efforts are needed to improve results of appropriateness of indication of
antiepileptic drugs.