HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

US EPA's regulatory pesticide evaluations need clearer guidelines for considering mammary gland tumors and other mammary gland effects.

Abstract
Breast cancer risk from pesticides may be missed if effects on mammary gland are not assessed in toxicology studies required for registration. Using US EPA's registration documents, we identified pesticides that cause mammary tumors or alter development, and evaluated how those findings were considered in risk assessment. Of 28 pesticides that produced mammary tumors, EPA's risk assessment acknowledges those tumors for nine and dismisses the remaining cases. For five pesticides that alter mammary gland development, the implications for lactation and cancer risk are not assessed. Many of the mammary-active pesticides activate pathways related to endocrine disruption: altering steroid synthesis in H295R cells, activating nuclear receptors, or affecting xenobiotic metabolizing enzymes. Clearer guidelines based on breast cancer biology would strengthen assessment of mammary gland effects, including sensitive histology and hormone measures. Potential cancer risks from several common pesticides should be re-evaluated, including: malathion, triclopyr, atrazine, propylene oxide, and 3-iodo-2-propynyl butylcarbamate (IPBC).
AuthorsBethsaida Cardona, Ruthann A Rudel
JournalMolecular and cellular endocrinology (Mol Cell Endocrinol) Vol. 518 Pg. 110927 (12 01 2020) ISSN: 1872-8057 [Electronic] Ireland
PMID32645345 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Endocrine Disruptors
  • Pesticides
Topics
  • Animals
  • Breast Neoplasms (chemically induced, pathology)
  • Endocrine Disruptors (pharmacology)
  • Female
  • Government Regulation
  • Humans
  • Mammary Glands, Animal (drug effects)
  • Mammary Glands, Human (drug effects)
  • Pesticides (toxicity)
  • Practice Guidelines as Topic (standards)
  • Risk Assessment
  • Toxicity Tests (methods, standards)
  • United States
  • United States Environmental Protection Agency (legislation & jurisprudence, standards)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: