Abstract | OBJECTIVE: METHOD: We analyzed double-blind, randomized, placebo-controlled trials of memantine add-on treatment in schizophrenia patients receiving antipsychotic medications. The primary outcome measure was amelioration of negative symptoms and the secondary outcome measures were amelioration of positive, total and general psychopathology symptoms. Publication bias was evaluated by Funnel plot and Egger test. RESULTS: Eleven studies (n=570) were included. Although memantine add-on treatment was superior to placebo for ameliorating negative symptoms (SMD=0.596, 95% CI=0.075-1.118, p=0.025), there were no statistically significant differences in the amelioration of general psychopathology (SMD=0.034, 95% CI=0.419-0.488, p=0.883), positive (SMD=-0.041, 95% CI=0.217-0.135, p=0.650) and overall (SMD=0.315, 95% CI=0.256-0.887, p=0.280) symptoms. No publication bias was observed between studies according to Funnel plots and Egger test results. CONCLUSION:
Memantine augmentation treatment seems to be beneficial for particularly treating negative symptoms in schizophrenia patients. Further studies with larger sample size and longer follow-up durations are needed.
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Authors | Sefa Vayısoğlu, Sevilay Karahan, A Elif Anıl Yağcıoğlu |
Journal | Turk psikiyatri dergisi = Turkish journal of psychiatry
(Turk Psikiyatri Derg)
Vol. 30
Issue 4
Pg. 253-259
( 2019)
ISSN: 2651-3463 [Electronic] Turkey |
Vernacular Title | Şizofreni Hastalarında Antipsikotik Tedavinin Memantin ile Güçlendirilmesi: Bir Sistematik Gözden Geçirme ve Metaanaliz. |
PMID | 32594486
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Chemical References |
- Antiparkinson Agents
- Antipsychotic Agents
- Memantine
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Topics |
- Antiparkinson Agents
(administration & dosage, therapeutic use)
- Antipsychotic Agents
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Humans
- Memantine
(administration & dosage, therapeutic use)
- Psychiatric Status Rating Scales
- Randomized Controlled Trials as Topic
- Schizophrenia
(drug therapy)
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