The Utility of IgA-Based Serologic Markers in Diagnosing Celiac Disease in Children 24 Months of Age or Younger.

Abstract

Current screening guidelines in North America for celiac disease recommend additional IgG based testing for younger children. Our multicenter retrospective study showed that the anti-tissue transglutaminase IgA antibody test should be the recommended initial test in all children, including those ≤24 months of age.

• Authors: Muhammad Rehan Khan, Jocelyn A Silvester, Brandon Sparks, Zackary Hintze, Tracy Ediger, Joseph J Larson, Ivor Hill, Imad Absah
• Journal: The Journal of pediatrics (J Pediatr) Vol. 224 Pg. 158-161.e2 (09 2020) ISSN: 1097-6833 [Electronic] United States
• PMID: 32593411 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Immunoglobulin A
• Protein Glutamine gamma Glutamyltransferase 2
• Transglutaminases
• GTP-Binding Proteins

Topics

• Biomarkers (blood)
• Case-Control Studies
• Celiac Disease (blood, diagnosis)
• Female
• GTP-Binding Proteins (blood)
• Humans
• IgA Deficiency (blood)
• Immunoglobulin A (blood)
• Infant
• Male
• Protein Glutamine gamma Glutamyltransferase 2
• Retrospective Studies
• Transglutaminases (blood)