Renal Manifestations in Children with Dengue Fever Hospitalized in Pediatric Intensive Care Unit.

Abstract

OBJECTIVE:

To study the pattern of acute kidney injury in children with dengue infection hospitalized in an intensive care unit.

METHODS:

This is a retrospective study from January 2019 through December 2019. Various renal manifestations of dengue were studied and compared between the severity of dengue fever.

RESULTS:

Three hundred nineteen children with dengue fever were hospitalized and 127 needed intensive care admission. Among the 127 patients, 26 (20.5%) children developed acute kidney injury (AKI). Children with severe dengue developed a higher number of AKI (n = 20; 28.6%), as compared to dengue with warning sign group (n = 6; 11.8%). Colloid infusion, inotropic support, ventilatory requirement and presence of secondary hemophagocytic lymphohistiocytosis were the risk factors for AKI. Nine children underwent dialysis. Among the AKI group, 23 recovered and 3 died and all three had multi organ dysfunction syndrome.

CONCLUSIONS:

It is essential to recognize the various renal manifestations of dengue AKI which is associated with increased mortality and morbidity.

• Authors: Mahalakshmi Rajan, Sangeetha Geminiganesan, Shuba Sankaranarayanan, Ramachandran Padmanaban, Mahalakshmi Panneer Selvam
• Journal: Indian journal of pediatrics (Indian J Pediatr) Vol. 87 Issue 12 Pg. 1014-1017 (Dec 2020) ISSN: 0973-7693 [Electronic] India
• PMID: 32557142 (Publication Type: Journal Article)

Topics

• Acute Kidney Injury (diagnosis, epidemiology, etiology)
• Child
• Dengue (complications, diagnosis, therapy)
• Humans
• Intensive Care Units, Pediatric
• Lymphohistiocytosis, Hemophagocytic
• Retrospective Studies
• Risk Factors