Autoantibodies to stratify systemic sclerosis patients into clinically actionable subsets.

Abstract

Systemic sclerosis (SSc) is a rare chronic disease of unknown etiology characterized by vascular abnormalities and fibrosis involving the skin and internal organs, especially the gastrointestinal tract, lung, heart and kidneys. Although the disease was historically stratified according to the extent of skin involvement, more recent approaches place more emphasis on patterns and extent of internal organ involvement. Despite numerous clinical trials, disease-modifying treatment options are still limited resulting in persistent poor quality of life and high mortality. This review provides an overview of autoantibodies in SSc and novel approaches to stratify the disease into clinically actionable subsets.

• Authors: Michael Mahler, Marie Hudson, Chelsea Bentow, Fabrece Roup, Lorenzo Beretta, Carmen Pilar Simeón, Alfredo Guillén-Del-Castillo, Sílvia Casas, Marvin J Fritzler
• Journal: Autoimmunity reviews (Autoimmun Rev) Vol. 19 Issue 8 Pg. 102583 (Aug 2020) ISSN: 1873-0183 [Electronic] Netherlands
• PMID: 32553611 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies

Topics

• Autoantibodies (blood, immunology)
• Humans
• Quality of Life
• Scleroderma, Systemic (immunology, pathology, therapy)