Abstract | AIM: Aim of the present study was to evaluate the loading of clindamycin with injectable- guided tissue regeneration (GTR) will prevent the colonization of Porphyromonas gingivalis and to compare and assess the quantitative changes in P. gingivalis colony forming units (CFUs) by real-time polymerase chain reaction (PCR) analysis. MATERIALS AND METHODS: Thirty microbiological samples were pooled from the deepest periodontal pockets from the thirty sites from the two groups: group I- injectable GTR placed in the defect filled with demineralized freeze-dried bone allograft (DFDBA) and group II- clindamycin loaded injectable GTR placed in the defect filled with DFDBA. The total number of P. gingivalis CFUs was estimated using real-time PCR at baseline and 4 weeks after therapy. RESULTS: A significant reduction in P. gingivalis CFUs at the end of 4 weeks was seen in both groups. Comparative evaluations between both groups at 4 weeks were with a mean of 4.44 ± 2.28 and 4.75 ± 3.32, respectively. Though there was a significant reduction in group II, the difference was statistically insignificant. CONCLUSION: The results suggest that clindamycin is beneficial in reducing microbial infection and can potentiate regeneration through host modulation. CLINICAL SIGNIFICANCE:
Injectable GTR has the ability to mold according to the defect size and shape and eliminates the need to manipulate the membrane as required for the conventional membrane.
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Authors | Voruganti Deepak, Johnson J Josephin, Palaparthy R Babu, Vikram R Guntakandla, Jagadish R Gooty, Suryakanth Malgikar, Abhinav Gupta |
Journal | The journal of contemporary dental practice
(J Contemp Dent Pract)
Vol. 21
Issue 1
Pg. 36-40
(Jan 01 2020)
ISSN: 1526-3711 [Electronic] India |
PMID | 32381798
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Bone Transplantation
- Clindamycin
- Guided Tissue Regeneration, Periodontal
- Porphyromonas gingivalis
- Real-Time Polymerase Chain Reaction
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