Abstract | BACKGROUND: Diagnosis of pancreatic diseases in dogs is still challenging because of variable clinical signs, which do not always correspond with clinical pathology and histopathological findings. OBJECTIVES: To characterize inflammatory and neoplastic pancreatic diseases of dogs and to correlate these findings with clinical findings and canine pancreatic lipase immunoreactivity (cPLI) results. ANIMALS: Tissue specimens and corresponding blood samples from 72 dogs submitted for routine diagnostic testing. METHODS: RESULTS: In dogs with normal pancreas, 92.5% of serum cPLI results were within the reference range and significantly lower than in dogs with mild acute pancreatitis, moderate or severe acute pancreatitis and pancreatic tumors. In dogs with moderate or severe acute pancreatitis, cPLI sensitivity was 90.9% (95% confidence interval [CI], 58.7%-99.8%). Most dogs (9/12) with pancreatic tumors (group 4) had additional pancreatic inflammation and cPLI results were increased in 10 dogs. CONCLUSIONS AND CLINICAL IMPORTANCE:
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Authors | Heike Aupperle-Lellbach, Katrin Törner, Marlies Staudacher, Christina Stadler, Ursula Tress, Julia M Grassinger, Elisabeth Müller, Corinna N Weber |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
Vol. 34
Issue 3
Pg. 1127-1134
(May 2020)
ISSN: 1939-1676 [Electronic] United States |
PMID | 32379386
(Publication Type: Journal Article)
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Copyright | © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. |
Chemical References |
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Topics |
- Animals
- Dog Diseases
(diagnosis, enzymology, pathology)
- Dogs
- Female
- Lipase
(blood, immunology)
- Male
- Pancreatic Neoplasms
(diagnosis, enzymology, veterinary)
- Pancreatitis
(diagnosis, enzymology, veterinary)
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