Introduction to molecular endocrine pathology.

Abstract

The applications of molecular techniques to endocrine pathology have been rapidly expanding in the past few years. This article reviews some of the basic concepts and techniques in molecular biology and summarizes recent applications of these techniques in the study of endocrine diseases. The applications of clonal analysis, hybridization techniques, single strand conformation polymorphism analysis, and the polymerase chain reaction technique in the study of neoplasms including specific mutations of oncogenes and suppressor genes in various endocrine tissues are discussed. The rapidly developing field of homeobox genes and their role in development including studies of normal pituitary development and pituitary tumor expression of the Pit-1 transcription factor, a member of the POU family of homeobox genes, are also summarized.Endocr Pathol 4:64-72, 1993.

• Authors: Ricardo V Lloyd
• Journal: Endocrine pathology (Endocr Pathol) Vol. 4 Issue 2 Pg. 64-72 (Jun 1993) ISSN: 1559-0097 [Electronic] United States
• PMID: 32370445 (Publication Type: Journal Article, Review)