Evaluation of Fixed Intrathecal Bupivacaine Infusion Doses in the Oncologic Population.

Abstract

OBJECTIVES:

Intrathecal drug delivery systems (IDDS) are an important method of pain control for patients with refractory oncologic pain. Local anesthetics such as bupivacaine have been infused either alone or with opioids. While effective, bupivacaine can cause adverse effects such as numbness, weakness, and urinary retention. This study looks to establish a safe and efficacious fixed bupivacaine dosing algorithm in intrathecal pumps for cancer patients.

MATERIALS AND METHODS:

A bupivacaine dosing algorithm was developed using data from 120 previous patients who underwent IDDS placement at Memorial Sloan Kettering Cancer Center. The outcomes were then evaluated for 43 subsequent patients who were treated with bupivacaine IDDS according to our aforementioned algorithm.

RESULTS:

Our data show that in patients treated with our bupivacaine guideline, visual analog pain scale scores decreased by 59% and oral morphine equivalence decreased by 70% from the period between IDDS implantation until discharge from the MSKCC hospital. However, 16.3% of our patients had bupivacaine-related side effects.

CONCLUSIONS:

For oncological patients, our data and experience support the initiation of intrathecal bupivacaine at the following doses: 5 mg/day for catheter tips in the cervical spine, 8 mg/day for catheter tips at T1-4, and 10 mg/day for catheter tips at T5-8. Given the higher likelihood of adverse effects in catheters at T9-12 and the lumbar spine, we start at 8 mg/day with close follow-up of the patient. Initiating these doses allow our patients to safely reach adequate analgesia faster, with a shorter hospitalization and quicker return to anti-cancer therapy.

• Authors: Grant H Chen, Matthew A Spiegel, Yan C Magram, Ehtesham Baig, Keith Clement, Ilya Laufer, Amitabh Gulati
• Journal: Neuromodulation : journal of the International Neuromodulation Society (Neuromodulation) Vol. 23 Issue 7 Pg. 984-990 (Oct 2020) ISSN: 1525-1403 [Electronic] United States
• PMID: 32343025 (Publication Type: Journal Article)
• Copyright: © 2020 International Neuromodulation Society.

Chemical References

• Anesthetics, Local
• Morphine
• Bupivacaine

Topics

• Algorithms
• Anesthetics, Local
• Bupivacaine (administration & dosage)
• Cancer Pain (drug therapy)
• Humans
• Injections, Spinal
• Morphine (therapeutic use)
• Pain, Intractable (drug therapy)