Abstract | BACKGROUND: The etiology of ulcerative colitis (UC) remains elusive even though many genetic and environmental pathogenic factors have been reported. Aberrant inflammatory responses mediated by specific subsets of T cells have been observed in ulcerative lesions of UC patients. OBJECTIVES: METHOD: We recruited 65 Japanese UC patients and 22 healthy controls (HC) and used the in vitro lymphocyte stimulation test to quantify their sensitivity to zinc, gold, nickel, and palladium - the metals that have been widely used in dentistry. All subjects were users of metallic dental implants and/or prostheses containing zinc, gold, nickel, and/or palladium as major constituents. RESULTS: Sixty percent of the UC patients were hypersensitive to at least one metal species, whereas 32% of the HC were hypersensitive to only a single metal species. The overall incidence of metal hypersensitivity was significantly higher for UC patients than for HC. Furthermore, a significantly greater proportion of UC patients were hypersensitive to nickel or palladium. The severity of the sensitivity to nickel and palladium was also significantly greater for UC patients than for HC. CONCLUSIONS:
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Authors | Yasunari Kageyama, Yutaka Shimokawa, Kimihiko Kawauchi, Masafumi Morimoto, Koichi Aida, Tetsu Akiyama, Tsutomu Nakamura |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 181
Issue 6
Pg. 456-461
( 2020)
ISSN: 1423-0097 [Electronic] Switzerland |
PMID | 32316004
(Publication Type: Journal Article)
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Copyright | © 2020 S. Karger AG, Basel. |
Chemical References |
- Dental Materials
- Palladium
- Gold
- Nickel
- Zinc
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Topics |
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Child
- Colitis, Ulcerative
(immunology)
- Dental Materials
(adverse effects)
- Female
- Gold
(adverse effects, immunology)
- Humans
- Hypersensitivity, Delayed
(chemically induced, complications, diagnosis, epidemiology)
- Incidence
- Male
- Middle Aged
- Nickel
(adverse effects, immunology)
- Palladium
(adverse effects, immunology)
- Pilot Projects
- Prevalence
- Young Adult
- Zinc
(adverse effects, immunology)
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