Abstract | BACKGROUND: METHODS:
Head and neck cancer patients (n = 60) undergoing tumor resection and reconstructive surgery were randomized 1:1 to RIPC or sham intervention administered intraoperatively. Blood samples were obtained preoperatively, 6 hours after RIPC/ sham, and on the first postoperative day. LP protein plasma levels were measured utilizing time-resolved immunofluorometric assays. RESULTS: H-ficolin and M-ficolin levels were significantly increased in cancer patients compared with healthy individuals (both P ≤ 0.02). Conversely, mannan-binding lectin (MBL)-associated serine protease (MASP)-1, MASP-3, collectin liver-1 (CL-L1), and MBL-associated protein of 44 kilodalton (MAp44) levels were decreased in cancer patients compared with healthy individuals (all P ≤ 0.04). A significant reduction in all LP protein levels was observed after surgery (all P < 0.001); however, RIPC did not affect LP protein levels. No difference was demonstrated in postoperative LP protein levels between patients who developed surgical site infection and patients who did not (all P > 0.13). CONCLUSIONS:
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Authors | Kristine Frederiksen, Andreas Engel Krag, Julie Brogaard Larsen, Birgitte Jul Kiil, Steffen Thiel, Anne-Mette Hvas |
Journal | PloS one
(PLoS One)
Vol. 15
Issue 4
Pg. e0230411
( 2020)
ISSN: 1932-6203 [Electronic] United States |
PMID | 32267878
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lectins
- ficolin
- Mannose-Binding Protein-Associated Serine Proteases
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Topics |
- Female
- Head and Neck Neoplasms
(complications, pathology, surgery)
- Humans
- Ischemic Preconditioning
- Lectins
(metabolism)
- Male
- Mannose-Binding Protein-Associated Serine Proteases
(metabolism)
- Middle Aged
- Reperfusion Injury
(pathology)
- Surgical Wound Infection
(complications)
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