An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis.

Abstract

PURPOSE:

To describe a patient with an amelanotic choroidal melanoma, originally misdiagnosed as a choroidal granuloma, following his systemic diagnosis of tattoo-associated sarcoidosis.

OBSERVATIONS:

The amelanotic choroidal tumor, suspected to be a granuloma, failed initial steroid treatment. Full-thickness chorioretinal biopsy demonstrated histologic presence of uveal melanoma and tumor genetics via GEP analysis demonstrated a PRAME negative, Class 1A lesion. The amelanotic choroidal melanoma was treated successfully with I-125 plaque brachytherapy.

CONCLUSION AND IMPORTANCE:

Despite a systemic diagnosis which predisposes a patient to uveal granuloma, amelanotic choroidal melanomas can still occur and should be considered. The association of uveal melanoma and sarcoidosis remains rare and of unclear significance.

• Authors: Sean T Berkowitz, Anderson L Brock, David A Reichstein
• Journal: American journal of ophthalmology case reports (Am J Ophthalmol Case Rep) Vol. 18 Pg. 100655 (Jun 2020) ISSN: 2451-9936 [Electronic] United States
• PMID: 32211561 (Publication Type: Case Reports)
• Copyright: © 2020 The Authors.