Functional roles of protein phosphatase 4 in multiple aspects of cellular physiology: a friend and a foe.

Abstract

Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been steadily studied over the past decade about wide spectrum of physiological activities in cells. Given the many vital functions in cells, PP4 has great potential to develop into the finding of key working mechanisms and effective treatments for related diseases such as cancer and diabetes. In this review, we provide an overview of the cellular and molecular mechanisms by which PP4 impacts and also discuss the functional significance of it in cell health. [BMB Reports 2020; 53(4): 181-190].

• Authors: Jaehong Park, Dong-Hyun Lee
• Journal: BMB reports (BMB Rep) Vol. 53 Issue 4 Pg. 181-190 (Apr 2020) ISSN: 1976-670X [Electronic] Korea (South)
• PMID: 32192570 (Publication Type: Journal Article, Review)

Chemical References

• Cell Cycle Proteins
• Phosphoprotein Phosphatases
• protein phosphatase 4
• Glucose

Topics

• Animals
• Apoptosis (physiology)
• Cell Cycle Checkpoints (physiology)
• Cell Cycle Proteins (physiology)
• DNA Repair (physiology)
• Genomic Instability (physiology)
• Glucose (metabolism)
• Humans
• Immunity (physiology)
• Phosphoprotein Phosphatases (genetics, metabolism)