Accelerated Phase of Atypical Chronic Myeloid Leukemia with Severe Disseminated Intravascular Coagulation at Initial Presentation.

Abstract

Patients with myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) are often asymptomatic and thus can remain undiagnosed until they become symptomatic due to progression to the accelerated phase (AP) or transformation to acute leukemia (leukemic transformation; LT). We herein report the case of a previously healthy 38-year-old man who had hyperleukocytosis with dysplastic myeloid precursor cells and severe disseminated intravascular coagulation. Hematopoietic recovery with features of atypical chronic myeloid leukemia (aCML) after induction chemotherapy was a diagnostic clue. Although rare, this case highlights the limitation of the diagnostic approach for aCML with AP or LT at the initial presentation.

• Authors: Mai Fujita, Kazuharu Kamachi, Masako Yokoo, Keisuke Kidoguchi, Kana Kusaba, Haruna Kizuka-Sano, Kyosuke Yamaguchi, Atsujiro Nishioka, Mariko Yoshimura, Yasushi Kubota, Toshihiko Ando, Kensuke Kojima, Shinya Kimura
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 59 Issue 12 Pg. 1549-1553 (Jun 15 2020) ISSN: 1349-7235 [Electronic] Japan
• PMID: 32188810 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Disseminated Intravascular Coagulation (complications)
• Humans
• Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (complications, drug therapy, pathology)
• Leukocytosis (complications)
• Male